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Ralista

Ralista 60 mg
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10 pills $7.00 $0.70 -

Ralista (Raloxifene hydrochloride) is a selective estrogen receptor modulator (SERM) that belongs to the benzothiophene class of compounds. Raloxifene's biological actions are largely mediated through binding to estrogen receptors. This binding results in activation of certain estrogenic pathways and blockade of others. Thus, Raloxifene is a selective estrogen receptor modulator (SERM).

Raloxifene decreases resorption of bone and reduces biochemical markers of bone turnover to the premenopausal range. These effects on bone are manifested as reductions in the serum and urine levels of bone turnover markers, decreases in bone resorption based on radiocalcium kinetics studies, increases in bone mineral density (BMD) and decreases in incidence of fractures. Ralista also has effects on lipid metabolism. Ralista decreases total and LDL cholesterol levels but does not increase triglyceride levels. It does not change total HDL cholesterol levels. Preclinical data demonstrate that raloxifene is an estrogen antagonist in uterine and breast tissues. Clinical trial data (through a median of 42 months) suggest that Raloxifene lacks estrogen-like effects on the uterus and breast tissue.

The recommended dosage is one 60 mg Ralista tablet daily, which may be administered any time of day without regard to meals. If you miss a dose of Ralista, skip the missed dose and go back to the regular dosing schedule. Do not take 2 doses at once.

Ralista is contraindicated in lactating women or women who are or may become pregnant. It may cause fetal harm when administered to a pregnant woman. Ralista is also contraindicated in women with active or past history of venous thromboembolic events, including deep vein thrombosis, pulmonary embolism, retinal vein thrombosis and in women known to be hypersensitive to raloxifene or other constituents of the tablets.

The safety of Ralista in the treatment of osteoporosis was assessed in a large multinational placebo-controlled trial. Common adverse events considered to be related to Raloxifene therapy were hot flashes and leg cramps. The majority of adverse events occurring during the study were mild and generally did not require discontinuation of therapy. These adverse events included infection, migraine, nausea, myalgia, insomnia, rash, conjunctivitis, vaginitis.

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